GLIDIMIN 2 AGLIDIMIN 2 A

GLIDIMIN 2

The combination of modern sulfonylurea (glimepiride) and metformin is widely prescribed for effective blood glucose control due to its capability of counteracting “insulin secretion disorder” and “insulin resistance,” respectively.

Category:

Description

Composition:

Each uncoated tablet contains:

Glimepride IP                                              2mg

Metformin Hydrochloride IP                   500mg

 

Mechanism:

Insulin stimulation effect varies according to sulfonylurea, and it is due to structural changes which would modify binding affinity to its receptor localized in the plasma membrane. The Sulfonylurea Receptor (SUR) belongs to the ATP-Binding Cassette family as a 140-170 kDa membrane protein. The SUR is structurally related to another protein called Inwardly Rectifying Potassium Channel and together they constitute the KATP channel, one of the major metabolic sensors in pancreatic beta cells.

At the molecular level, metformin inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity (via effects on fat metabolism) and lowering cAMP, thus reducing the expression of gluconeogenic enzymes.

 

Indication:

It is indicated for the treatment of Type 2 diabetes

 

Dosage:

 

1 tablet once daily or to be taken in a dose and duration as directed by the Physician.

 

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